Company profile: Entrada Therapeutics
1.1 - Company Overview
Company description
- Provider of a proprietary EEV platform to target and engage typically inaccessible intracellular disease targets, with therapeutic programs using EEV-oligonucleotides. Pipeline includes Duchenne muscular dystrophy candidates ENTR-601-44, ENTR-601-45 and ENTR-601-50 for exon skipping to restore dystrophin, and a myotonic dystrophy type 1 program to restore MBNL protein activity in collaboration with Vertex.
Products and services
- Duchenne Muscular Dystrophy Program: Oligonucleotide-based program developing EEV-Oligonucleotides to address genetic causes and restore functional dystrophin in muscle cells using targeted intracellular engagement
- EEV™ Platform: Proprietary platform that targets and engages disease-causing targets within cells typically inaccessible, supporting therapeutic applications across diverse areas with intracellular target access
- Myotonic Dystrophy Type 1 Program: MBNL-targeted program architected with EEV-Oligonucleotides to restore MBNL protein activity in myotonic dystrophy type 1, advanced via collaboration with Vertex.
Key contacts
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Financial details
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1.2 - Competitors and similar companies to Entrada Therapeutics
GeneTx Biotherapeutics
HQ: United States
Website
- Description: Provider of biotechnology therapeutics focused on Angelman syndrome, offering investigational gene and antisense therapies. Pipeline includes GTX-102 for Angelman syndrome (delivering a functional UBE3A gene to the brain), UX055 for CDKL5 Deficiency Disorder, and UX111 for Sanfilippo syndrome type A, with a commitment to clinical trial transparency including trial registration, results publication, and data sharing.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
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- Total funding raised: $●●●m
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Harmony Biosciences
HQ: United States
Website
- Description: Provider of novel therapies for rare neurological disorders, including U.S. commercialization of pitolisant, a histamine-3 receptor antagonist/inverse agonist approved for narcolepsy; developing HBS-102, a melanin-concentrating hormone receptor 1 antagonist; and evaluating pitolisant for idiopathic hypersomnia, Prader-Willi syndrome, and myotonic dystrophy.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
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Amryt Pharma
HQ: Ireland
Website
- Description: Provider of specialty pharmaceuticals for rare and orphan diseases: Myalept/Myalepta (metreleptin) for leptin deficiency complications in generalized or partial lipodystrophy; Mycapssa (octreotide capsules) for long-term maintenance therapy in acromegaly; Juxtapid/Lojuxta (lomitapide) for adults with HoFH; Filsuvez (Oleogel-S10) for partial-thickness wounds in junctional and dystrophic EB; and AP103, a pre-clinical gene therapy for DEB.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
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Castle Creek Biosciences
HQ: United States
Website
- Description: Provider of personalized gene therapies for rare skin and connective tissue disorders, including D-Fi (dabocemagene autoficel) for dystrophic epidermolysis bullosa using autologous genetically modified fibroblasts to express type VII collagen; an autologous fibroblast technology platform; in-house cGMP commercial-scale manufacturing; and an expanded access policy for investigational products.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
- Backers: ●●●●●●●●●●
- Acquisitions: ●●
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Aspreva Pharmaceuticals
HQ: Canada
Website
- Description: Provider of pharmaceutical solutions focused on identifying, developing and commercializing new indications for approved drugs and drug candidates for underserved patient populations. Headquartered in Victoria, British Columbia, the company uses a collaboration strategy termed 'indication partnering'.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
- Backers: ●●●●●●●●●●
- Acquisitions: ●●
View full Aspreva Pharmaceuticals company profile →
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2.M&A buyers
2.1 Potential strategic acquirers in the sector
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2.2 - Strategic buyer groups for Entrada Therapeutics
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3. Investors and private equity firms
3.1 - Buyout funds investing in similar companies to Entrada Therapeutics
2.2 - Growth funds investing in similar companies to Entrada Therapeutics
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4 - Top valuation comps for Entrada Therapeutics
4.2 - Public trading comparable groups for Entrada Therapeutics
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