Company profile: MacroGenics
1.1 - Company Overview
Company description
- Provider of immunotherapeutics, including antibody-drug conjugates and DART bispecifics targeting B7-H3, PD-1ΓCTLA-4 and CD123, to treat metastatic castration-resistant prostate cancer, advanced solid tumors, CD123-positive neoplasms (AML, MDS) and multiple cancers; programs include vobramitamab duocarmazine, lorigerlimab, MGD024, MGC026, MGC028 and enoblituzumab.
Products and services
- Lorigerlimab: A tetravalent PD-1 Γ CTLA-4 DART molecule developed to treat metastatic castration-resistant prostate cancer in combination with docetaxel
- Vobramitamab Duocarmazine (vobra duo): A B7-H3-targeted antibody-drug conjugate engineered for treating metastatic castration-resistant prostate cancer, with plans for application across additional cancers
- MGD024: A DART-based CD123 Γ CD3 molecule created to treat CD123-positive neoplasms, including acute myeloid leukemia and myelodysplastic syndromes
Key contacts
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Financial details
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1.2 - Competitors and similar companies to MacroGenics
Inviragen
HQ: United States
Website
- Description: Provider of life-saving vaccines in development to protect against emerging infectious diseases worldwide, including a lead dengue fever vaccine and a West Nile virus vaccine for North America.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: βββββ
- Total funding raised: $βββm
- Backers: ββββββββββ
- Acquisitions: ββ
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TG Therapeutics
HQ: United States
Website
- Description: Provider of biopharmaceutical therapies for hematologic malignancies and autoimmune disorders, including BRIUMVI, a treatment for relapsing forms of multiple sclerosisβclinically isolated syndrome, relapsing-remitting disease, and active secondary progressive diseaseβin adults.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: βββββ
- Total funding raised: $βββm
- Backers: ββββββββββ
- Acquisitions: ββ
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CellPoint
HQ: The Netherlands
Website
- Description: Provider of point-of-care CAR-T therapy solutions enabling clinicians to retarget patient immune cells to treat hematological malignancies, with a 6-day manufacturing process powered by the proprietary xCellit real-time monitoring software system that allows for 1 week vein-to-vein time, making therapies more affordable and accessible.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: βββββ
- Total funding raised: $βββm
- Backers: ββββββββββ
- Acquisitions: ββ
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Immunovant
HQ: United States
Website
- Description: Provider of clinical-stage biopharmaceutical offerings focused on enabling normal lives for patients with autoimmune diseases.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: βββββ
- Total funding raised: $βββm
- Backers: ββββββββββ
- Acquisitions: ββ
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Avaxia Biologics
HQ: United States
Website
- Description: Provider of orally delivered, gut-targeted antibody therapeutics using a proprietary platform, including Avaximab-TNF for local intestinal anti-TNF action in inflammatory bowel disease; AVX-470, an oral anti-TNF polyclonal antibody from bovine milk evaluated in Phase 1b for ulcerative colitis; and the Avaximabs platform for recombinant antibodies that withstand the GI environment and act locally.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: βββββ
- Total funding raised: $βββm
- Backers: ββββββββββ
- Acquisitions: ββ
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2.M&A buyers
2.1 Potential strategic acquirers in the sector
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2.2 - Strategic buyer groups for MacroGenics
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Buyer group 1: ββββββββ ββββββββ
ββ companies
Description: ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ
Key Products: ββββββββ, ββββββββ, ββββββββ, ββββββββ
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Buyer group 2: ββββββββ ββββββββ
ββ companies
Description: ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ
Key Products: ββββββββ, ββββββββ, ββββββββ, ββββββββ
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Buyer group 3: ββββββββ ββββββββ
ββ companies
Description: ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ ββββββββ
Key Products: ββββββββ, ββββββββ, ββββββββ, ββββββββ
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3. Investors and private equity firms
3.1 - Buyout funds investing in similar companies to MacroGenics
2.2 - Growth funds investing in similar companies to MacroGenics
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4 - Top valuation comps for MacroGenics
4.2 - Public trading comparable groups for MacroGenics
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