Company profile: American Gene Technologies
1.1 - Company Overview
Company description
- Provider of gene therapy solutions for infectious diseases, cancers, and inherited disorders. Offerings include AGT103-T, an autologous genetically modified cell product to repair HIV-related immune damage and enable natural control of replication; a PKU gene therapy expected to enter trials in 2025; an immuno-oncology program activating γδ T cells to destroy solid tumors; and a proprietary gene-delivery platform.
Products and services
- AGT103-T: An autologous genetically modified cell product that repairs HIV-induced immune damage and restores natural control of viral replication, currently in clinical trials pursuing a possible HIV cure
- Gene-Delivery Platform: A proprietary development system that accelerates creation of gene-therapy products aimed at curing infectious diseases, cancers, and inherited disorders
- Phenylketonuria (PKU) Gene Therapy: A synthetic gene therapy targeting PKU that architects corrective expression to treat the inherited disease, with clinical trials expected in 2025
Key contacts
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Financial details
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1.2 - Competitors and similar companies to American Gene Technologies
Genenta
HQ: Italy
Website
- Description: Provider of gene transfer therapy for cancer, including Temferon, a lentiviral hematopoietic stem progenitor cell immunotherapy enabling controlled, targeted interferon-α expression within tumors to generate immune responses to TEMs-positive cancers. Offers a proprietary cell-based platform using hematopoietic stem cells to deliver therapeutic payloads in the tumor microenvironment for durable, safe treatment of solid tumors.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
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Sirna Therapeutics
HQ: United States
Website
- Description: Provider of biotechnology research and development focused on RNA interference (RNAi) for human disease therapy, creating RNAi-based therapies to ultimately treat patients.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
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Akouos
HQ: United States
Website
- Description: Provider of AAV vector-based gene therapies to restore and preserve hearing in genetically defined patient populations, addressing causes from single gene mutations to ototoxic drug exposure and aging. Offers AK-OTOF, a gene therapy targeting sensorineural hearing loss due to otoferlin mutations, and the Resonate Program, no-cost genetic testing with optional counseling for auditory neuropathy.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
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Kriya Therapeutics
HQ: United States
Website
- Description: Provider of gene therapies for ophthalmology, neurology, and metabolic diseases, including KRIYA-825 for geographic atrophy (inhibiting C3/C5; one-time suprachoroidal), KRIYA-586 for thyroid eye disease (blocking IGF1 receptor), KRIYA-839 for diabetes (insulin and glucokinase), KRIYA-497 for NASH (FGF21), and KRIYA-748 and KRIYA-382 for trigeminal neuralgia and focal epilepsy via chemogenetically gated ion channels.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
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Avidity Biosciences
HQ: United States
Website
- Description: Provider of oligonucleotide-based therapies leveraging an Antibody Oligonucleotide Conjugates (AOCs) platform that combines monoclonal antibodies with oligonucleotides to target genetic drivers of disease. Pipeline includes AOC 1001 for DM1 (Phase 3) to reduce DMPK mRNA, AOC 1020 for FSHD (Phase 1/2) to reduce DUX4 mRNA/protein, and AOC 1044 for DMD exon 44 skipping (Phase 1/2).
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
- Company type: Private company
- Employees: ●●●●●
- Total funding raised: $●●●m
- Backers: ●●●●●●●●●●
- Acquisitions: ●●
View full Avidity Biosciences company profile →
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2.M&A buyers
2.1 Potential strategic acquirers in the sector
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2.2 - Strategic buyer groups for American Gene Technologies
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3. Investors and private equity firms
3.1 - Buyout funds investing in similar companies to American Gene Technologies
2.2 - Growth funds investing in similar companies to American Gene Technologies
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4 - Top valuation comps for American Gene Technologies
4.2 - Public trading comparable groups for American Gene Technologies
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