Company profile: Cellestia
1.1 - Company Overview
Company description
- Provider of clinical-stage R&D therapies to control and modulate pathogenic gene expression via selective inhibition of transcription factors in the cell nucleus. Lead candidate CB-103 targets the CSL-NOTCH complex and is in Phase 2 for various cancers and GvHD, showing efficacy in multi-drug resistant cancers and autoimmune diseases. Pipeline includes preclinical assets for psoriasis, Sjogrenβs, SLE, IBD and giant cell arteritis.
Products and services
- CB-103: A clinical-stage drug candidate inhibiting the CSL-NOTCH transcription complex, showing efficacy in multi-drug resistant cancers and autoimmune diseases
- Phase 2 trials ongoing in multiple cancer types and GvHD
- Selective transcription factor inhibition approach: A nucleus-targeted program that architects therapies to modulate pathogenic gene expression across diseases by selective inhibition of transcription factors within the cell nucleus
- Pre-clinical candidates: Preclinical pipeline assets targeting psoriasis, Sjogrenβs syndrome, systemic lupus erythematosus, inflammatory bowel disease, and giant cell arteritis
- IND-enabling and First-in-Human studies planned within 12β18 months.
Key contacts
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Financial details
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1.2 - Competitors and similar companies to Cellestia
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Nerio Therapeutics
HQ: United States
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- Description: Provider of biotechnology for the life sciences sector; founded in 2019 and based in La Jolla, CA, USA.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
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CG Oncology
HQ: United States
Website
- Description: Provider of clinical-stage oncolytic immunotherapies targeting cancer, centered on the investigational agent cretostimogene grenadenorepvec for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). Activities include Phase 3 trials BOND-003 (monotherapy in high-risk BCG-unresponsive NMIBC) and PIVOT-006 (intermediate-risk NMIBC), and the Phase 2 CORE-001 combination with pembrolizumab in high-risk BCG-unresponsive NMIBC.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
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Endocare
HQ: United States
Website
- Description: Provider of medical devices and related consumables for cryoablation, developing, manufacturing, and distributing these products.
- Rationale: This competitor operates in a highly similar market segment with overlapping features.
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2.M&A buyers
2.1 Potential strategic acquirers in the sector
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2.2 - Strategic buyer groups for Cellestia
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Buyer group 2: ββββββββ ββββββββ
ββ companies
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Buyer group 3: ββββββββ ββββββββ
ββ companies
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3. Investors and private equity firms
3.1 - Buyout funds investing in similar companies to Cellestia
2.2 - Growth funds investing in similar companies to Cellestia
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4 - Top valuation comps for Cellestia
4.2 - Public trading comparable groups for Cellestia
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